She was the only child of Michel and Cornelia Silberman.

She married Sandu Horodniceanu in December 1955, shortly after graduating from Medical School. Leni earned her PhD in 1965.

From 1961 until 1989 she worked at Bucharest Oncological Institute. In October 1989 she immigrated to Israel where she continued to work in her field at Rambam Hospital in Haifa until her retirement.

This picture was taken in Washington, DC in August 2000.